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estrogen receptor antagonist ici 182 780  (MedChemExpress)


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    MedChemExpress estrogen receptor antagonist ici 182 780
    (A, B) OVX mice were treated with an estrogen receptor selective antagonist <t>ICI</t> <t>182,780</t> (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
    Estrogen Receptor Antagonist Ici 182 780, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 144 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/estrogen+receptor+antagonist+ici+182+780/Fulvestrant/pmc12285542-61-17-24
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    1) Product Images from "Regulation of Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Expression by Estrogen in the Mouse Uterine Endometrium"

    Article Title: Regulation of Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Expression by Estrogen in the Mouse Uterine Endometrium

    Journal: Development & Reproduction

    doi: 10.12717/DR.2025.29.2.31

    (A, B) OVX mice were treated with an estrogen receptor selective antagonist ICI 182,780 (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
    Figure Legend Snippet: (A, B) OVX mice were treated with an estrogen receptor selective antagonist ICI 182,780 (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.

    Techniques Used: Injection, Expressing, Western Blot, Immunofluorescence, Control, Negative Control, Staining, Binding Assay

    Related Articles

    Expressing:

    Article Title: Regulation of Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Expression by Estrogen in the Mouse Uterine Endometrium
    Article Snippet: .. To determine whether the expression of TAZ in the mouse uterus is dependent on estrogen receptors, an estrogen receptor antagonist ICI 182,780 (500 μg/mouse, Medchemexpress, Princeton, NJ, USA) was pretreated 30 min before estrogen treatment ( ). .. Sesame oil (100 μL/mouse, Acros Organics, Geel, Belgium) was used for control mice.



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    (A, B) OVX mice were treated with an estrogen receptor selective antagonist <t>ICI</t> <t>182,780</t> (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
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    (A, B) OVX mice were treated with an estrogen receptor selective antagonist <t>ICI</t> <t>182,780</t> (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
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    (A, B) OVX mice were treated with an estrogen receptor selective antagonist <t>ICI</t> <t>182,780</t> (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
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    (A, B) OVX mice were treated with an estrogen receptor selective antagonist <t>ICI</t> <t>182,780</t> (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.
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    Image Search Results


    (A, B) OVX mice were treated with an estrogen receptor selective antagonist ICI 182,780 (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.

    Journal: Development & Reproduction

    Article Title: Regulation of Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Expression by Estrogen in the Mouse Uterine Endometrium

    doi: 10.12717/DR.2025.29.2.31

    Figure Lengend Snippet: (A, B) OVX mice were treated with an estrogen receptor selective antagonist ICI 182,780 (ICI, 500 μg/mouse) 30 min before estrogen (E 2 , 200 ng/mouse) injection and sacrificed at 6 h after E 2 administration. TAZ expression was analyzed by western blot analysis. The relative protein intensity of TAZ in western blot was analyzed by the ImageJ program. Data were shown with mean±SEM. The one-way ANOVA analysis and Tukey’s test were used to calculate the p-value, ** p <0.01, *** p <0.001. (C) Immunofluorescence images showed the localization and expression of TAZ (red) in uteri of OVX mice treated with oil, E 2 , or a combination of ICI and E 2 . Normal rabbit IgG (IgG control) was used as a negative control. DAPI (blue) was used for nuclei staining. The scale bars indicate 20 μm. Taz , transcriptional coactivator with PDZ-binding motif; LE, luminal epithelium; GE, glandular epithelium; OVX, ovariectomized.

    Article Snippet: To determine whether the expression of TAZ in the mouse uterus is dependent on estrogen receptors, an estrogen receptor antagonist ICI 182,780 (500 μg/mouse, Medchemexpress, Princeton, NJ, USA) was pretreated 30 min before estrogen treatment ( ).

    Techniques: Injection, Expressing, Western Blot, Immunofluorescence, Control, Negative Control, Staining, Binding Assay